VARIABILITY AND RESISTANCE MUTATIONS IN THE HEPATITIS C VIRUS NS3 PROTEASE IN PATIENTS NOT TREATED WITH PROTEASE INHIBITORS

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

The goal of treatment of chronic hepatitis C is to achieve a sustained virological response, which is defined as exhibiting undetectable hepatitis C virus (HCV) RNA levels in serum following therapy for at least six months.However, the current treatment is only effective in 50% of patients infected with HCV genotype 1, the most prevalent genotype i

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Seed dormancy loss from dry after-ripening is associated with increasing gibberellin hormone levels in Arabidopsis thaliana

IntroductionThe seeds of many plants are dormant and unable to germinate at maturity, but gain the ability to germinate through after-ripening during dry storage.The hormone abscisic acid (ABA) stimulates seed dormancy, whereas gibberellin A (GA) stimulates dormancy loss and germination.MethodsTo determine whether dry after-ripening alters the pote

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Conceptualizing resistance to the Americanization of finance in advanced economy states: The case of the Canadian-dollar system

This article Top derives four propositions for conceptualizing resistance to the Americanization of finance in advanced economy states.Resistance entails truncation of market-based financial innovations in line with political profit-sharing arrangements between governments, bankers, and other coalitional interests locked in a game of bank bargains.

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Pulmonary Toxicity and Inflammatory Response of Vape Cartridges Containing Medium-Chain Triglycerides Oil and Vitamin E Acetate: Implications in the Pathogenesis of EVALI

Recently, there has been an outbreak of a condition named e-cigarette or vaping products-associated lung injury (EVALI).The primary components of vaping products include tetrahydrocannabinol Eye Patch (THC), vitamin E acetate (VEA) and medium-chain triglycerides (MCT), may be responsible for acute lung toxicity.Currently, little information is avai

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Reporting frequency of potentially malignant oral disorders and oral cancer: A 10-year retrospective data analysis in a teaching dental institution

Introduction: Incidence of oral potentially malignant and malignant lesions is increasing, thereby escalating the burden of cancer on our nation.Oral cancer and preceding lesions are of utmost importance for the present scenario.Various risk factors predominantly, consumption USB Extenders of tobacco with other synergetic products affect the oral m

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